Research Scientist II – Teachey Laboratory
Children »s Hospital of Philadelphia Posted on 2022-11-18
| Salary | Not mentioned |
|---|---|
| Location | Philadelphia, PA 19104 (University City area) |
| Type | Full-time |
Job Description
Location: LOC_COLKET-Colket Translational Research
Req ID: 221893
Shift: Any
Employment Status: Regular – Full Time
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Children’s Hospital of Philadelphia (CHOP)—named America’s 2022 Best Large Employer by Forbes—offers countless ways to change lives. Our diverse community of more than 20,000 Breakthrough Makers will inspire you to pursue passions, develop expertise, and drive innovation.
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CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children.
We strongly encourage all candidates of diverse backgrounds and lived experiences to apply.
Job Summary
A Research Scientist II position is available in the laboratory of Dr. David Teachey at the Center for Childhood Cancer Research at the Children’s Hospital of Philadelphia (CHOP) and the University of Pennsylvania (UPENN). This position is part of a research program to understand the molecular mechanisms of acute leukemia as a means to develop novel therapeutic approaches in both precision medicine and immunotherapy. The laboratory uses patient derived xenograft mouse models generated as well as cell lines to recapitulate the human disease. We also lead large genomic profiling efforts in T-cell acute lymphoblastic leukemia and lymphoma, performing bulk sequencing as well as single cell profiling of thousands of patient samples from children treated on clinical trials. Our lab has translated multiple small molecule inhibitors and immunotherapies into the clinic. Often we perform pre-clinical drug development in the lab, design and lead the affiliated clinical trials (both local and international) and then receive and test correlative patient samples from those trials to study mechanisms of response and resistance to novel treatments including CAR-T.
Strong experimental skill in basic molecular biology techniques are a prerequisite (DNA, RNA, protein analysis, protein pull downs, cloning, cell culture, multi-parameter flow cytometry, cytotoxicity, apoptosis and cell cycle assays)
Strong preference will be given to candidates with the at least two or more of following specific skills:
- Experience in research in bulk (whole genome and whole transciptome sequencing) and single cell omic profiling (scRNAseq, scATACseq).
- Experience in mouse hematopoiesis and leukemia models, including leukemia xenografts.
- Experience in research involving primary patient material including regulatory aspects of this type of research and interaction with other researchers/groups within collaborative projects.
Job Responsibilities
- Conducts research of significant scientific value in the basic and/or translational science area(s) relevant to their practice specialty.
- Responsible for design, planning and conduct of multiple experiments.
- Trains technical staff, students, fellows & physicians in lab procedures.
- Supervises junior staff to ensure correct procedures are followed.
- Provides general supervision over the laboratory.
- Assists in management of resource allocations and day-to-day activities.
- Composes publications for peer reviewed, scientific, quality and management journals.
- Participates in procurement of additional funding through contributions to proposal development.
- Collaborates with researchers, external agencies and institutions to develop cooperative research initiatives.
- Responsible for appropriate use of research funds.
- Participates in educational programs and teaching assignments.
Job Responsibilities (Continued)
Job Responsibilities (Continued)
Required Licenses, Certifications, Registrations
None
Required Education and Experience
Required Education:
- Master »s Degree
Required Experience:
- At least two (2) years scientifically relevant post-fellowship experience.
Preferred Education, Experience & Cert/Lic
Preferred Education:
- Doctorate with two (2) years or more of Post-Doctoral fellowship or scientifically relevant experience OR
- Master »s Degree with ten (10) or more years of scientifically relevant experience
Preferred Experience:
- Post-Doctoral fellowship experience.
Additional Technical Requirements
- Up to 50% of individual effort is self-funded(preferred).
- Scientific/intellectual contributions characterized by the unique & autonomous creativity
To carry out its mission, CHOP is committed to supporting the health of our patients, families, workforce, and global community. As a condition of employment, professionals working onsite—at any CHOP location, for any portion of time—must be vaccinated for COVID-19. Learn more.
CHOP also requires employees who work in patient care buildings to receive an annual influenza vaccine. Employees may request exemptions for valid religious and medical reasons. Start dates may be delayed until candidates are immunized or exemption requests are reviewed.
EEO / VEVRAA Federal Contractor | Tobacco Statement
Company description:
At Children »s Hospital of Philadelphia (CHOP), we help children grow and thrive — and we offer these same opportunities to the professionals who make up our team. CHOP is a unique work environment, with exceptional team members, supportive managers and state-of-the-art training. Our employees are all empowered to realize their well-defined goals, because we believe everyone makes a difference — it’s the very foundation on which our hospital is built. Since 1855, CHOP has been the birthplace of many dramatic firsts in pediatric medicine. As the nation »s first hospital devoted exclusively to caring for children, CHOP has fostered medical discoveries and innovations that have improved pediatric healthcare and saved the lives of countless children. Today, that same spirit of care and innovation continues. The hospital now employs more than 10,000 people in more than 50 locations across Pennsylvania and New Jersey.
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